A total fibrinogen deficiency is compatible with the development of pulmonary fibrosis in mice.

@article{Ploplis2000ATF,
  title={A total fibrinogen deficiency is compatible with the development of pulmonary fibrosis in mice.},
  author={Victoria A. Ploplis and Justin D Wilberding and Linda McLennan and Zheng-dong Liang and Ivo P Cornelissen and Melanie E Deford and Elliot D. Rosen and Francis J. Castellino},
  journal={The American journal of pathology},
  year={2000},
  volume={157 3},
  pages={703-8}
}
In addition to their well-known roles in hemostasis, fibrinogen (Fg) and fibrin (Fn) have been implicated in a number of other physiological and pathophysiological events. One of these involves the fibroproliferative response after acute lung injury, which is the focus of the current study. Mice with a total Fg deficiency (FG(-/-)) were generated by breeding heterozygous (FG(+/-)) pairs, each of which contained an allele with a targeted deletion of its Fg-gamma-chain gene. The resulting FG… CONTINUE READING