A top-down systems biology view of microbiome-mammalian metabolic interactions in a mouse model

@article{Martn2007ATS,
  title={A top-down systems biology view of microbiome-mammalian metabolic interactions in a mouse model},
  author={F. de Juan Mart{\'i}n and Marc-Emmanuel Dumas and Yulan L Wang and Cristina Legido-Quigley and Ivan Yap and Huiru R. Tang and S{\'e}verine Zirah and Gerard M. Murphy and Olivier Cloarec and John C. Lindon and Norbert Sprenger and Laurent Bernard Fay and Sunil Kochhar and Peter J. van Bladeren and Elaine Holmes and Jeremy K. Nicholson},
  journal={Molecular Systems Biology},
  year={2007},
  volume={3},
  pages={70 - 80}
}
Symbiotic gut microorganisms (microbiome) interact closely with the mammalian host's metabolism and are important determinants of human health. Here, we decipher the complex metabolic effects of microbial manipulation, by comparing germfree mice colonized by a human baby flora (HBF) or a normal flora to conventional mice. We perform parallel microbiological profiling, metabolic profiling by (1)H nuclear magnetic resonance of liver, plasma, urine and ileal flushes, and targeted profiling of bile… CONTINUE READING
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