A tool for multiple sequence alignment.

  title={A tool for multiple sequence alignment.},
  author={David J. Lipman and Stephen F. Altschul and John D. Kececioglu},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={86 12},
Multiple sequence alignment can be a useful technique for studying molecular evolution and analyzing sequence-structure relationships. Until recently, it has been impractical to apply dynamic programming, the most widely accepted method for producing pairwise alignments, to comparisons of more than three sequences. We describe the design and application of a tool for multiple alignment of amino acid sequences that implements a new algorithm that greatly reduces the computational demands of… CONTINUE READING
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