A tonic gamma-aminobutyric acid-mediated inhibition of cholinergic amacrine cells in rabbit retina.

@article{Massey1982ATG,
  title={A tonic gamma-aminobutyric acid-mediated inhibition of cholinergic amacrine cells in rabbit retina.},
  author={Stephen C. Massey and Dianna A. Redburn},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1982},
  volume={2 11},
  pages={1633-43}
}
Using the in vivo rabbit eyecup, we have studied the light-evoked release of acetylcholine (ACh) which is presumed to indicate the activity of cholinergic amacrine cells. Gamma-Aminobutyric acid (GABA) inhibited the light-evoked release of ACh (IC50 congruent to 1 mM), but the GABA antagonists bicuculline (5 micro M) and picrotoxin (20 micro M) potentiated the light-evoked release and markedly increased the resting release of ACh. This bicuculline/picrotoxin-evoked release was calcium dependent… CONTINUE READING

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