A tocotrienol-enriched formulation protects against radiation-induced changes in cardiac mitochondria without modifying late cardiac function or structure.

@article{Sridharan2015ATF,
  title={A tocotrienol-enriched formulation protects against radiation-induced changes in cardiac mitochondria without modifying late cardiac function or structure.},
  author={Vijayalakshmi Sridharan and Preeti Tripathi and Nukhet Aykin-Burns and Kimberly J. Krager and Sunil K Sharma and Eduardo G. Moros and Stepan Melnyk and Oleksandra Pavliv and Martin Hauer-Jensen and Marjan Boerma},
  journal={Radiation research},
  year={2015},
  volume={183 3},
  pages={357-66}
}
Radiation-induced heart disease (RIHD) is a common and sometimes severe late side effect of radiation therapy for intrathoracic and chest wall tumors. We have previously shown that local heart irradiation in a rat model caused prolonged changes in mitochondrial respiration and increased susceptibility to mitochondrial permeability transition pore (mPTP) opening. Because tocotrienols are known to protect against oxidative stress-induced mitochondrial dysfunction, in this study, we examined the… CONTINUE READING

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