A-to-I RNA Editing Up-regulates Human Dihydrofolate Reductase in Breast Cancer.

Abstract

Dihydrofolate reductase (DHFR) plays a key role in folate metabolism and is a target molecule of methotrexate. An increase in the cellular expression level of DHFR is one of the mechanisms of tumor resistance to methotrexate. The present study investigated the possibility that adenosine-to-inosine RNA editing, which causes nucleotide conversion by adenosine… (More)
DOI: 10.1074/jbc.M117.775684

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