A tissue-specific knockout reveals that Gata1 is not essential for Sertoli cell function in the mouse.

@article{Lindeboom2003ATK,
  title={A tissue-specific knockout reveals that Gata1 is not essential for Sertoli cell function in the mouse.},
  author={Fokke Lindeboom and Nynke Gillemans and Alar Karis and Martine Jaegle and Dies Meijer and Frank Grosveld and Sjaak Philipsen},
  journal={Nucleic acids research},
  year={2003},
  volume={31 18},
  pages={5405-12}
}
The transcription factor Gata1 is essential for the development of erythroid cells. Consequently, Gata1 null mutants die in utero due to severe anaemia. Outside the haematopoietic system, Gata1 is only expressed in the Sertoli cells of the testis. To elucidate the function of Gata1 in the testis, we made a Sertoli cell-specific knockout of the Gata1 gene in the mouse. We deleted a normally functioning 'floxed' Gata1 gene in pre-Sertoli cells in vivo through the expression of Cre from a… CONTINUE READING

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