A tissue-engineered humanized xenograft model of human breast cancer metastasis to bone

@inproceedings{Thibaudeau2014ATH,
  title={A tissue-engineered humanized xenograft model of human breast cancer metastasis to bone},
  author={Laure Thibaudeau and Anna Verena Taubenberger and Boris Michael Holzapfel and Verena M C Quent and Tobias Fuehrmann and Parisa Hesami and Toby David Brown and Paul D Dalton and Carl Andrew Power and Brett George Hollier and Dietmar Werner Hutmacher},
  booktitle={Disease models & mechanisms},
  year={2014}
}
The skeleton is a preferred homing site for breast cancer metastasis. To date, treatment options for patients with bone metastases are mostly palliative and the disease is still incurable. Indeed, key mechanisms involved in breast cancer osteotropism are still only partially understood due to the lack of suitable animal models to mimic metastasis of human tumor cells to a human bone microenvironment. In the presented study, we investigate the use of a human tissue-engineered bone construct to… CONTINUE READING
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