A time to kill: viral manipulation of the cell death program.

@article{Hay2002ATT,
  title={A time to kill: viral manipulation of the cell death program.},
  author={Stewart Lister Hay and George Kannourakis},
  journal={The Journal of general virology},
  year={2002},
  volume={83 Pt 7},
  pages={
          1547-64
        }
}
Many viruses have as part of their arsenal the ability to modulate the apoptotic pathways of the host. It is counter-intuitive that such simple organisms would be efficient at regulating this the most crucial pathway within the host, given the relative complexity of the host cells. Yet, viruses have the potential to initiate or stay the onset of programmed cell death through the manipulation of a variety of key apoptotic proteins. It is the intention of this review to provide an overview of… CONTINUE READING

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