A time course study on the "in vitro" effects of T3 and testosterone on androgen and estrogen receptors in peripuberal primary rat Sertoli cells.

@article{Sisci1997ATC,
  title={A time course study on the "in vitro" effects of T3 and testosterone on androgen and estrogen receptors in peripuberal primary rat Sertoli cells.},
  author={Diego Sisci and Maria Luisa Panno and Mariacarolina Salerno and Marcello Maggiolini and Vincenzo Pezzi and E. G. Morrone and L. Di Mauro and Saveria Aquila and Stefania Marsico and Marilena Lanzino and Sebastiano And{\'o}},
  journal={Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association},
  year={1997},
  volume={105 4},
  pages={218-24}
}
The effect of Tri-iodothyronine (T3) administration leading to the precocius differentiation of Sertoli cell in prepuberal rats has been previously shown. The functional maturation of Sertoli cells is associated with changes in androgen metabolism. We have recently demonstrated that T3 influences androgen metabolism in Sertoli cells by inhibiting aromatase activity and reduces drastically the ER contents in peripubertal hypothyroid rats. To better understand the role of T3 in modulating steroid… CONTINUE READING