A time course study of acute traumatic coagulopathy prior to resuscitation: from hypercoagulation to hypocoagulation caused by hypoperfusion?

@article{Duan2014ATC,
  title={A time course study of acute traumatic coagulopathy prior to resuscitation: from hypercoagulation to hypocoagulation caused by hypoperfusion?},
  author={Kaipeng Duan and Wenkui Yu and Zhiliang Lin and Shanjun Tan and Xiaowu Bai and Ling Xu and Yi Dong and Ning Li},
  journal={Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis},
  year={2014},
  volume={50 3},
  pages={399-406}
}
INTRODUCTION Coagulopathy after sever injury predicts the requirements of blood products, organ failure and mortality in traumatic patients. The early onset and complexity of traumatic coagulopathy preclude the understanding the underlying mechanism. The aim of the study is to characterize the early coagulation alteration in a swine model with multi-trauma and shock. METHODS Twelve pigs were subjected to multi-trauma (femur fracture, laparotomy, 10 cm intestine resection and grade III injury… CONTINUE READING