A time course of orchestrated endophilin action in sensing, bending, and stabilizing curved membranes


Numerous proteins act in concert to sculpt membrane compartments for cell signaling and metabolism. These proteins may act as curvature sensors, membrane benders, and scaffolding molecules. Here we show that endophilin, a critical protein for rapid endocytosis, quickly transforms from a curvature sensor into an active bender upon membrane association. We… (More)
DOI: 10.1091/mbc.E16-04-0264