A tiered hidden Markov model characterizes multi-scale chromatin states.


Precise characterization of chromatin states is an important but difficult task for understanding the regulatory role of chromatin. A number of computational methods have been developed with varying levels of success. However, a remaining challenge is to model epigenomic patterns over multi-scales, as each histone mark is distributed with its own… (More)
DOI: 10.1016/j.ygeno.2013.03.009


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