A thyrotoxic skeletal phenotype of advanced bone formation in mice with resistance to thyroid hormone.

@article{OShea2003ATS,
  title={A thyrotoxic skeletal phenotype of advanced bone formation in mice with resistance to thyroid hormone.},
  author={Patrick J. O'Shea and Clare B Harvey and Hideyo Suzuki and Masahiro Kaneshige and Kumiko Kaneshige and Sheue-yann Cheng and Graham R Williams},
  journal={Molecular endocrinology},
  year={2003},
  volume={17 7},
  pages={1410-24}
}
Thyroid hormone (T3) regulates bone turnover and mineralization in adults and is essential for skeletal development during childhood. Hyperthyroidism is an established risk factor for osteoporosis. Nevertheless, T3 actions in bone remain poorly understood. Patients with resistance to thyroid hormone, due to mutations of the T3-receptor beta (TRbeta) gene, display variable phenotypic abnormalities, particularly in the skeleton. To investigate the actions of T3 during bone development, we… CONTINUE READING
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