A threshold of transmembrane potential is required for mitochondrial dynamic balance mediated by DRP1 and OMA1

@inproceedings{Jones2016ATO,
  title={A threshold of transmembrane potential is required for mitochondrial dynamic balance mediated by DRP1 and OMA1},
  author={Edith E. Banks Linda Susan Day Marian Rita Halpin Norman Jones and Norma Gaytan and Iraselia Garcia and Alan Herrera and Manuel Jos{\'e} Moreno Ramos and Divya Agarwala and Maahrose Rana and Wendy Innis-Whitehouse and Erin Schuenzel and Robert Gilkerson},
  booktitle={Cellular and Molecular Life Sciences},
  year={2016}
}
As an organellar network, mitochondria dynamically regulate their organization via opposing fusion and fission pathways to maintain bioenergetic homeostasis and contribute to key cellular pathways. This dynamic balance is directly linked to bioenergetic function: loss of transmembrane potential across the inner membrane (Δψ m) disrupts mitochondrial fission/fusion balance, causing fragmentation of the network. However, the level of Δψ m required for mitochondrial dynamic balance, as well as the… CONTINUE READING
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Metabolic regulation of mitochondrial dynamics

The Journal of cell biology • 2016
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