A threshold effect of the major isoforms of NCAM on neurite outgrowth

@article{Doherty1990ATE,
  title={A threshold effect of the major isoforms of NCAM on neurite outgrowth},
  author={Patrick Doherty and Manuel Fruns and Patricia Seaton and George Dickson and Christopher Barton and Thomas A. Sears and Frank S. Walsh},
  journal={Nature},
  year={1990},
  volume={343},
  pages={464-466}
}
INTERACTIONS between recognition molecules on the surface of neuronal growth cones and guidance cues present in the local cellular environment are thought to account for the growth of neurites in the highly stereospecific manner that contributes to correct target cell innervation1–3. In vitro assays have been used to identify candidate molecular components of this system, either directly by demonstrating their ability to promote neurite outgrowth4,5, or indirectly by the ability of specific… CONTINUE READING