A three-step strategy for targeting drug carriers to human ovarian carcinoma cells in vitro.

@article{Xiao2002ATS,
  title={A three-step strategy for targeting drug carriers to human ovarian carcinoma cells in vitro.},
  author={Zili Xiao and S. A. McQuarrie and M. R. Suresh and J. R. Mercer and Shraman Gupta and G. G. Miller},
  journal={Journal of biotechnology},
  year={2002},
  volume={94 2},
  pages={171-84}
}
To improve tumor-to-tissue ratios of anticancer agents in radioimmunotherapy, a three-step targeting approach was used to deliver biotinylated liposomes to human ovarian cancer cells (NIH:OVCAR-3, SK-OV-3) in vitro. Targeting was based upon the use of two antibodies specific for the CA-125 antigen that is highly expressed on NIH:OVCAR-3 cells but not expressed on SK-OV-3 cells. Briefly, the approach consists of prelabeling target cells with biotinylated anti-CA-125 antibody and FITC-labeled… CONTINUE READING

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