A three-step model for the synaptic recruitment of AMPA receptors.

  title={A three-step model for the synaptic recruitment of AMPA receptors.},
  author={Patricio Meza Opazo and Daniel Choquet},
  journal={Molecular and cellular neurosciences},
  volume={46 1},
The amount of AMPARs at synapses is not a fixed number but varies according to different factors including synaptic development, activity and disease. Because the number of AMPARs sets the strength of synaptic transmission, their trafficking is subject to fine and tight regulation. In this review, we will describe the different steps taken by AMPARs in order to reach the synapse. We propose a three-step mechanism involving exocytosis at extra/perisynaptic sites, lateral diffusion to synapses… CONTINUE READING
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