A three-step mechanism of action of thyroid hormone and mesenchyme in metamorphic changes in anuran larval skin.

The mesenchyme of the anuran tadpole has been known to induce the regional specificity of epidermis which is expressed during metamorphosis as a body (head and trunk)-or a tail-specific change: the former epidermis transforms into the adult-type, while the latter commits programmed cell death. The inductive activity of the mesenchyme was characterized in… (More)