A three-state model for the regulation of telomerase by TERRA and hnRNPA1

@inproceedings{Redon2013ATM,
  title={A three-state model for the regulation of telomerase by TERRA and hnRNPA1},
  author={Sophie Redon and Ivo Zemp and Joachim Lingner},
  booktitle={Nucleic acids research},
  year={2013}
}
Telomeres, the physical ends of eukaryotic chromosomes, are transcribed into telomeric repeat-containing RNA (TERRA), a large non-coding RNA, which forms an integral part of telomeric heterochromatin. In vitro, naked TERRA molecules are efficient inhibitors of human telomerase, base-pairing via their 5'-UUAGGG-3' repeats with the template sequence of telomerase RNA, in addition to contacting the telomerase reverse transcriptase protein subunit. In vivo, however, TERRA-mediated inhibition of… CONTINUE READING
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