A three-layered electrospun matrix to mimic native arterial architecture using polycaprolactone, elastin, and collagen: a preliminary study.

@article{McClure2010ATE,
  title={A three-layered electrospun matrix to mimic native arterial architecture using polycaprolactone, elastin, and collagen: a preliminary study.},
  author={Michael J. McClure and Scott A Sell and David G. Simpson and Beat Hans Walpoth and Gary L Bowlin},
  journal={Acta biomaterialia},
  year={2010},
  volume={6 7},
  pages={2422-33}
}
Throughout native artery, collagen, and elastin play an important role, providing a mechanical backbone, preventing vessel rupture, and promoting recovery under pulsatile deformations. The goal of this study was to mimic the structure of native artery by fabricating a multi-layered electrospun conduit composed of poly(caprolactone) (PCL) with the addition of elastin and collagen with blends of 45-45-10, 55-35-10, and 65-25-10 PCL-ELAS-COL to demonstrate mechanical properties indicative of… CONTINUE READING

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