A three-dimensional view of precursor messenger RNA metabolism within the mammalian nucleus.

@article{Carter1993ATV,
  title={A three-dimensional view of precursor messenger RNA metabolism within the mammalian nucleus.},
  author={Kevin C Carter and David Bowman and Walter A. Carrington and Keir Fogarty and John A McNeil and Fredric S. Fay and J B Lawrence},
  journal={Science},
  year={1993},
  volume={259 5099},
  pages={1330-5}
}
A quantitative three-dimensional analysis of nuclear components involved in precursor messenger RNA metabolism was performed with a combination of fluorescence hybridization, immunofluorescence, and digital imaging microscopy. Polyadenylate [poly(A)] RNA-rich transcript domains were discrete, internal nuclear regions that formed a ventrally positioned horizontal array in monolayer cells. A dimmer, sometimes strand-like, poly(A) RNA signal was dispersed throughout the nucleoplasm. Spliceosome… CONTINUE READING
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