A three-dimensional perspective on exon binding by a group II self-splicing intron.

@article{Costa2000ATP,
  title={A three-dimensional perspective on exon binding by a group II self-splicing intron.},
  author={Miguel Costa and François Michel and Eric Westhof},
  journal={The EMBO journal},
  year={2000},
  volume={19 18},
  pages={5007-18}
}
We have used chemical footprinting, kinetic dissection of reactions and comparative sequence analysis to show that in self-splicing introns belonging to subgroup IIB, the sites that bind the 5' and 3' exons are connected to one another by tertiary interactions. This unanticipated arrangement, which contrasts with the direct covalent linkage that prevails in the other major subdivision of group II (subgroup IIA), results in a unique three-dimensional architecture for the complex between the… CONTINUE READING

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