A three-dimensional in vitro model of tumor cell intravasation.

@article{Ehsan2014ATI,
  title={A three-dimensional in vitro model of tumor cell intravasation.},
  author={Seema Mai Ehsan and Katrina Marie Welch-Reardon and Marian L Waterman and Christopher C. W. Hughes and Steven C. George},
  journal={Integrative biology : quantitative biosciences from nano to macro},
  year={2014},
  volume={6 6},
  pages={
          603-10
        }
}
Metastasis is the cause of over 90% of all human cancer deaths. Early steps in the metastatic process include: the formation of new blood vessels, the initiation of epithelial-mesenchymal transition (EMT), and the mobilization of tumor cells into the circulation. There are ongoing efforts to replicate the physiological landscape of human tumor tissue using three-dimensional in vitro culture models; however, few systems are able to capture the full range of authentic, complex in vivo events such… CONTINUE READING

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