A three-dimensional collagen matrix as a suitable culture system for the comparison of cyclic strain and hydrostatic pressure effects on intervertebral disc cells.

@article{NeidlingerWilke2005ATC,
  title={A three-dimensional collagen matrix as a suitable culture system for the comparison of cyclic strain and hydrostatic pressure effects on intervertebral disc cells.},
  author={Cornelia Neidlinger-Wilke and Karin Wuertz and Astrid Liedert and Carla Schmidt and Wolfgang B{\"o}rm and Anita Ignatius and Hans-Joachim Wilke and Lutz Claes},
  journal={Journal of neurosurgery. Spine},
  year={2005},
  volume={2 4},
  pages={457-65}
}
OBJECT To study intervertebral disc cell mechanobiology, the authors developed experimental systems that allow the application of cyclic strain and intermittent hydrostatic pressure (IHP) on isolated disc cells under equal three-dimensional (3D) culture conditions. The purpose of the study was to characterize disc cell proliferation, viability, morphology, and gene expression in 3D collagen matrices. METHODS The effects of cyclic strain (1, 2, 4, and 8% strain; 1 Hz) and IHP (0.25 MPa, 0.1 Hz… CONTINUE READING
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