A thorough QT study to evaluate the effects of therapeutic and supratherapeutic doses of delafloxacin on cardiac repolarization.

@article{Litwin2015ATQ,
  title={A thorough QT study to evaluate the effects of therapeutic and supratherapeutic doses of delafloxacin on cardiac repolarization.},
  author={Jeffrey S Litwin and Michael Scott Benedict and Michael D. Thorn and Laura E. Lawrence and Sue Cammarata and Eugene F Sun},
  journal={Antimicrobial agents and chemotherapy},
  year={2015},
  volume={59 6},
  pages={
          3469-73
        }
}
A randomized, double-blind, placebo-controlled, 4-period crossover study was conducted in 52 healthy adults to assess the effect of delafloxacin on the corrected QT (QTc) interval. The QT interval, corrected for heart rate using Fridericia's formula (QTcF), was determined predose and at 0.5, 1, 1.25, 1.5, 1.75, 2, 2.5, 3, 4, 5, 6, 12, 18, and 24 h after dosing with delafloxacin at 300 mg intravenously (i.v.; therapeutic), delafloxacin at 900 mg i.v. (supratherapeutic), moxifloxacin at 400 mg… CONTINUE READING

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