A thiolase of Mycobacterium tuberculosis is required for virulence and production of androstenedione and androstadienedione from cholesterol.

@article{Nesbitt2010ATO,
  title={A thiolase of Mycobacterium tuberculosis is required for virulence and production of androstenedione and androstadienedione from cholesterol.},
  author={Natasha M. Nesbitt and Xinxin Yang and Patricia A. Font{\'a}n and I. Yu. Kolesnikova and Issar Smith and Nicole S Sampson and Eugenie J Dubnau},
  journal={Infection and immunity},
  year={2010},
  volume={78 1},
  pages={275-82}
}
Mycobacterium tuberculosis, the causative agent of tuberculosis, is an intracellular pathogen that shifts to a lipid-based metabolism in the host. Moreover, metabolism of the host lipid cholesterol plays an important role in M. tuberculosis infection. We used transcriptional profiling to identify genes transcriptionally regulated by cholesterol and KstR (Rv3574), a TetR-like repressor. The fadA5 (Rv3546) gene, annotated as a lipid-metabolizing thiolase, the expression of which is upregulated by… CONTINUE READING
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