A thermostable 35-residue subdomain within villin headpiece.

@article{McKnight1996AT3,
  title={A thermostable 35-residue subdomain within villin headpiece.},
  author={C. James McKnight and D S Doering and Paul Matsudaira and Peter S. Kim},
  journal={Journal of molecular biology},
  year={1996},
  volume={260 2},
  pages={126-34}
}
The actin-bundling protein villin contains, at its extreme C terminus, a compact f-actin binding domain called "headpiece". This 76-amino acid domain from chicken is highly thermostable. Here, we show that the stable folded structure in headpiece is localized to a subdomain formed by the C-terminal 35 residues. The subdomain, denoted HP-35, is monomeric and… CONTINUE READING