A thermoresponsive, microtextured substrate for cell sheet engineering with defined structural organization.

@article{Isenberg2008ATM,
  title={A thermoresponsive, microtextured substrate for cell sheet engineering with defined structural organization.},
  author={Brett C. Isenberg and Yukiko Tsuda and Corin Williams and Tatsuya Shimizu and Masayuki Yamato and T. Okano and Joyce Y. Wong},
  journal={Biomaterials},
  year={2008},
  volume={29 17},
  pages={2565-72}
}
The proper function of many tissues depends critically on the structural organization of the cells and matrix of which they are comprised. Therefore, in order to engineer functional tissue equivalents that closely mimic the unique properties of native tissues it is necessary to develop strategies for reproducing the complex, highly organized structure of these tissues. To this end, we sought to develop a simple method for generating cell sheets that have defined ECM/cell organization using… CONTINUE READING
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