A thermodynamic molecular switch in biological systems: ribonuclease S' fragment complementation reactions.

@article{Chun2000ATM,
  title={A thermodynamic molecular switch in biological systems: ribonuclease S' fragment complementation reactions.},
  author={Paul W. Chun},
  journal={Biophysical journal},
  year={2000},
  volume={78 1},
  pages={416-29}
}
It is well known that essentially all biological systems function over a very narrow temperature range. Most typical macromolecular interactions show DeltaH degrees (T) positive (unfavorable) and a positive DeltaS degrees (T) (favorable) at low temperature, because of a positive (DeltaCp degrees /T). Because DeltaG degrees (T) for biological systems shows a complicated behavior, wherein DeltaG degrees (T) changes from positive to negative, then reaches a negative value of maximum magnitude… CONTINUE READING

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