A thermodynamic framework for understanding temperature sensing by transient receptor potential (TRP) channels.

@article{Clapham2011ATF,
  title={A thermodynamic framework for understanding temperature sensing by transient receptor potential (TRP) channels.},
  author={David E Clapham and Christopher Miller},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2011},
  volume={108 49},
  pages={19492-7}
}
The exceptionally high temperature sensitivity of certain transient receptor potential (TRP) family ion channels is the molecular basis of hot and cold sensation in sensory neurons. The laws of thermodynamics dictate that opening of these specialized TRP channels must involve an unusually large conformational standard-state enthalpy, ΔH(o): positive ΔH(o) for heat-activated and negative ΔH(o) for cold-activated TRPs. However, the molecular source of such high-enthalpy changes has eluded… CONTINUE READING

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