A thermodynamic basis for prebiotic amino acid synthesis and the nature of the first genetic code.

  title={A thermodynamic basis for prebiotic amino acid synthesis and the nature of the first genetic code.},
  author={Paul G. Higgs and Ralph E. Pudritz},
  volume={9 5},
Of the 20 amino acids used in proteins, 10 were formed in Miller's atmospheric discharge experiments. The two other major proposed sources of prebiotic amino acid synthesis include formation in hydrothermal vents and delivery to Earth via meteorites. We combine observational and experimental data of amino acid frequencies formed by these diverse mechanisms and show that, regardless of the source, these 10 early amino acids can be ranked in order of decreasing abundance in prebiotic contexts… 

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