A thermo-responsive alginate nanogel platform co-loaded with gold nanoparticles and cisplatin for combined cancer chemo-photothermal therapy.

@article{Mirrahimi2019ATA,
  title={A thermo-responsive alginate nanogel platform co-loaded with gold nanoparticles and cisplatin for combined cancer chemo-photothermal therapy.},
  author={Mehri Mirrahimi and Ziaeddin Abed and Jaber Beik and Isaac Shiri and Amin Shiralizadeh Dezfuli and Vahid Pirhajati Mahabadi and S Kamran Kamrava and H Ghaznavi and Ali Shakeri-Zadeh},
  journal={Pharmacological research},
  year={2019},
  volume={143},
  pages={
          178-185
        }
}
The current interest in cancer research is being shifted from individual therapy to combinatorial therapy. In this contribution, a novel multifunctional nanoplatform comprising alginate nanogel co-loaded with cisplatin and gold nanoparticles (AuNPs) has been firstly developed to combine photothermal therapy and chemotherapy. The antitumor efficacy of the as-prepared nanocomplex was tested against CT26 colorectal tumor model. The nanocomplex showed an improved chemotherapy efficacy than free… CONTINUE READING

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