A therapeutic target for prostate cancer based on angiogenin-stimulated angiogenesis and cancer cell proliferation.

@article{Yoshioka2006ATT,
  title={A therapeutic target for prostate cancer based on angiogenin-stimulated angiogenesis and cancer cell proliferation.},
  author={Norie Yoshioka and Li Wang and Koji Kishimoto and Takanori Tsuji and Guo-fu Hu},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 39},
  pages={
          14519-24
        }
}
Human angiogenin is progressively up-regulated in the prostate epithelial cells during the development of prostate cancer from prostate intraepithelial neoplasia (PIN) to invasive adenocarcinoma. Mouse angiogenin is the most up-regulated gene in AKT-induced PIN in prostate-restricted AKT transgenic mice. These results prompted us to study the role that angiogenin plays in prostate cancer. Here, we report that, in addition to its well established role in mediating angiogenesis, angiogenin also… CONTINUE READING
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