A theory of drug action based on the rate of drug-receptor combination

@article{Paton1961ATO,
  title={A theory of drug action based on the rate of drug-receptor combination},
  author={William Drummond Macdonald Paton},
  journal={Proceedings of the Royal Society of London. Series B. Biological Sciences},
  year={1961},
  volume={154},
  pages={21 - 69}
}
A theory of drug action is developed on the assumption that excitation by a stimulant drug is proportional to the rate of drug-receptor combination, rather than to the proportion of receptors occupied by the drug. The properties of a drug can then be specified by two rate constants: k$_{1}$, the association rate constant, and k$_{2}$, the dissociation rate constant; the ratio k$_{2}$/k$_{1}$ = k$_{e}$ corresponds to the reciprocal of the 9affinity9. The value of k$_{e}$ then determines potency… CONTINUE READING

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The mode of action of drugs on cells

J.Physiol
  • 1933