A theory of drug action based on the rate of drug-receptor combination
@article{Paton1961ATO,
title={A theory of drug action based on the rate of drug-receptor combination},
author={William Drummond Macdonald Paton},
journal={Proceedings of the Royal Society of London. Series B. Biological Sciences},
year={1961},
volume={154},
pages={21 - 69}
}A theory of drug action is developed on the assumption that excitation by a stimulant drug is proportional to the rate of drug-receptor combination, rather than to the proportion of receptors occupied by the drug. The properties of a drug can then be specified by two rate constants: k$_{1}$, the association rate constant, and k$_{2}$, the dissociation rate constant; the ratio k$_{2}$/k$_{1}$ = k$_{e}$ corresponds to the reciprocal of the 9affinity9. The value of k$_{e}$ then determines potency… CONTINUE READING
