# A theory of drug action based on the rate of drug-receptor combination

```@article{Paton1961ATO,
title={A theory of drug action based on the rate of drug-receptor combination},
author={William Drummond Macdonald Paton},
journal={Proceedings of the Royal Society of London. Series B. Biological Sciences},
year={1961},
volume={154},
pages={21 - 69}
}```
A theory of drug action is developed on the assumption that excitation by a stimulant drug is proportional to the rate of drug-receptor combination, rather than to the proportion of receptors occupied by the drug. The properties of a drug can then be specified by two rate constants: k\$_{1}\$, the association rate constant, and k\$_{2}\$, the dissociation rate constant; the ratio k\$_{2}\$/k\$_{1}\$ = k\$_{e}\$ corresponds to the reciprocal of the 9affinity9. The value of k\$_{e}\$ then determines potency… CONTINUE READING

J.Physiol
• 1933