A theoretical study of the composition of the alveolar air at altitude.

  title={A theoretical study of the composition of the alveolar air at altitude.},
  author={Wallace O. Fenn and Hermann Rahn and Arthur B. Otis},
  journal={The American journal of physiology},
In our studies of high altitude physiology we have found an oxygen-carbon dioxide diagram a very great aid to accurate thinking. It has been useful in so many different problems that we consider it worth while to describe it in this paper so that it can be made available to others. 1. Breathing pure oxygen. In this diagram the alveolar tensions of carbon dioxide are plotted as ordinates against the alveolar tensions of oxygen as abscissae as in figure 1, which represents the situation when an… 
Equivalent Air Altitude and the Alveolar Gas Equation.
  • J. Conkin
  • Environmental Science
    Aerospace medicine and human performance
  • 2016
Those that use NH as a convenient surrogate for HH must concede that physiological responses to NH cannot be identical to the responses to HH given only equivalent hypoxic PIo₂.
Analysis of the respiratory response to carbon dioxide inhalation in varying clinical states of hypercapnia, anoxia, and acid-base derangement.
Individuals with cor pulmonale secondary to chronic pulmonary emphysema tend to have pulmonary ventilation which is less than normal both at rest and during exercise, despite the presence of factors
The measurement of gaseous exchange during nitrous oxide anaesthesia.
A method is described for the estimation of carbon dioxide output, oxygen uptake, and respiratory exchange ratio during nitrous oxide anaesthesia, using a box-bag system and a polaro-graph.
Alveolo-arterial gas exchange at rest and during work at different 02 tensions.
It is concluded that the arterial oxygen deficit when breathing normal air both at rest and during maximal work is caused by true venous admixture (anatomical shunts) and the effect of uneven distribution in the lungs, and that the lung diffusion capacity for O2 is not possible on the basis of the alveolo-end pulmonary capillary O2 gradient.
The alveolar gas equation: do lessons from WW2 research into high flying pilots provide insights into the adaptation to high altitude flight in birds?
Two related arguments are developed that avian blood gas predictions, based on the theory of multicapillary serial arterialization (MSA), are inaccurate and the primary adaptation to hypobaric hypoxia is the same for both classes and consists of defending PaO2 by reducing PaCO2 through increasing hyperventilation.
Approximate Simulation of Acute Hypobaric Hypoxia with Normobaric Hypoxia
There is not a sufficient integrated physiological understanding of the determinants of P(sub A)O2 and P( sub A)CO2 under acute NH and HH given the same hypoxic pO2 to claim a device that provides isohypoxia, so at best, the claim should be that the devices provide an approximate HH experience.
Arterial blood gases and respiratory response to simulated high altitude hypoxia in the pigeon (Columba livia)
The avian system showed no advantage for preventing hypocapnic disturbance of blood arterial P^q over the mammalian system, and the problem of consumption by avian nucleated erythrocytes during the interval required for membrane equi­ libration of blood gas analysis is discussed.


J. Hyg
  • J. Hyg
  • 1941