A theoretical radiobiological assessment of the influence of radionuclide half-life on tumor response in targeted radiotherapy when a constant kidney toxicity is maintained.

@article{AbouJaoud2004ATR,
  title={A theoretical radiobiological assessment of the influence of radionuclide half-life on tumor response in targeted radiotherapy when a constant kidney toxicity is maintained.},
  author={Wassim Abou-Jaoud{\'e} and Roger Dale},
  journal={Cancer biotherapy & radiopharmaceuticals},
  year={2004},
  volume={19 3},
  pages={308-21}
}
The potential of targeted radionuclide therapy may be limited if the antibody affinity to the tumor is relatively low and if significant normal tissue damage occurs while the tumor is sterilized. One way to increase the efficiency of the antibody-radionuclide complex might be to use knowledge of the radiobiological processes to select a near-optimal radionuclide half-life. In this paper, the role of physical half-life in targeted radiotherapy optimization is investigated using the linear… CONTINUE READING