A theoretical model for intraperitoneal delivery of cisplatin and the effect of hyperthermia on drug penetration distance.

@article{ElKareh2004ATM,
  title={A theoretical model for intraperitoneal delivery of cisplatin and the effect of hyperthermia on drug penetration distance.},
  author={Ardith W. El-Kareh and Timothy W. Secomb},
  journal={Neoplasia},
  year={2004},
  volume={6 2},
  pages={117-27}
}
A theoretical model for the intraperitoneal (i.p.) delivery of cisplatin and heat to tumor metastases in tissues adjacent to the peritoneal cavity is presented. The penetration distance (the depth to which drug diffuses directly from the cavity into tissues) is predicted to be on the order of 0.5 mm. The model shows that exchange with the microvasculature has more effect than cellular uptake in limiting the penetration distance. Possible effects of hyperthermia are simulated, including… CONTINUE READING

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