A theoretical framework for estimating cerebral oxygen metabolism changes using the calibrated-BOLD method: Modeling the effects of blood volume distribution, hematocrit, oxygen extraction fraction, and tissue signal properties on the BOLD signal

@article{Griffeth2011ATF,
  title={A theoretical framework for estimating cerebral oxygen metabolism changes using the calibrated-BOLD method: Modeling the effects of blood volume distribution, hematocrit, oxygen extraction fraction, and tissue signal properties on the BOLD signal},
  author={Valerie E. M. Griffeth and Richard B. Buxton},
  journal={NeuroImage},
  year={2011},
  volume={58 1},
  pages={198-212}
}
Calibrated blood oxygenation level dependent (BOLD) imaging, a technique used to measure changes in cerebral O(2) metabolism, depends on an accurate model of how the BOLD signal is affected by the mismatch between changes in cerebral blood flow (CBF) and cerebral metabolic rate of O(2) (CMRO(2)). However, other factors such as the cerebral blood volume (CBV) distribution at rest and with activation also affect the BOLD signal. The Davis model originally proposed for calibrated BOLD studies… CONTINUE READING
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