A theoretical examination of hydrogen sulfide metabolism and its potential in autocrine/paracrine oxygen sensing.

@article{Olson2013ATE,
  title={A theoretical examination of hydrogen sulfide metabolism and its potential in autocrine/paracrine oxygen sensing.},
  author={Kenneth R. Olson},
  journal={Respiratory physiology & neurobiology},
  year={2013},
  volume={186 2},
  pages={173-9}
}
Hydrogen sulfide (H2S) metabolism has been proposed as the oxygen (O2) sensing mechanism coupling hypoxia to effector responses in a variety of tissues including vascular and chemoreceptor cells. Implicit in this sensing system is a mechanism for regulating intracellular H2S concentration, presumably through oxidation. However, verification of this mechanism, or any other pathway of H2S signaling has been hampered by the lack of suitable methods for measuring intracellular concentration and… CONTINUE READING

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