A theoretical analysis of the effect of airway smooth muscle load on airway narrowing.

@article{Macklem1996ATA,
  title={A theoretical analysis of the effect of airway smooth muscle load on airway narrowing.},
  author={Peter T. Macklem},
  journal={American journal of respiratory and critical care medicine},
  year={1996},
  volume={153 1},
  pages={83-9}
}
  • Peter T. Macklem
  • Published 1996 in
    American journal of respiratory and critical care…
We used published data for the elastic properties of a 2-mm outer-diameter canine bronchus and assumed values for the thickness of the wall components and lung parenchymal shear modulus to estimate the load on airway smooth muscle and its effect on airway narrowing. The following relationships were calculated: (1) luminal and smooth muscle radii of curvature and transmural pressure; (2) the isovolume, transmural pressures developed by the smooth muscle to narrow the lumen at distending… CONTINUE READING
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