A theoretical analysis of the contributions of remodeling space, mineralization, and bone balance to changes in bone mineral density during alendronate treatment.

@article{Hernandez2001ATA,
  title={A theoretical analysis of the contributions of remodeling space, mineralization, and bone balance to changes in bone mineral density during alendronate treatment.},
  author={Christopher J Hernandez and Gary S. Beaupr{\'e} and R Marcus and Dennis R. Carter},
  journal={Bone},
  year={2001},
  volume={29 6},
  pages={511-6}
}
In patients with osteoporosis, alendronate treatment causes an increase in bone mineral density (BMD) and a decrease in fracture incidence. Alendronate acts by changing the bone remodeling process. Changes in bone remodeling resulting in decreased remodeling space, increased bone balance per remodeling cycle, and increased mineralization (ash mass/bone mass) have all been associated with alendronate treatment. Understanding the relative contributions of these parameters to BMD increases could… CONTINUE READING

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