A thallium transport FLIPR-based assay for the identification of KCC2-positive modulators.

  title={A thallium transport FLIPR-based assay for the identification of KCC2-positive modulators.},
  author={Di Zhang and Sujatha M Gopalakrishnan and Gail M. Freiberg and Carol S. Surowy},
  journal={Journal of biomolecular screening},
  volume={15 2},
KCC2, potassium chloride cotransporter 2, is expressed exclusively in the CNS (on inhibitory neurons) and plays a major role in maintaining appropriately low intracellular chloride levels that ensure inhibitory actions of GABA(A) and glycine receptors. As such, it plays a pivotal role in inhibitory mechanisms that control neuronal excitation in the CNS. KCC2 downregulation has been implicated in various excitatory disorders, such as epilepsy and neuropathic pain. Positive modulators of KCC2… CONTINUE READING


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