A thallium transport FLIPR-based assay for the identification of KCC2-positive modulators.

@article{Zhang2010ATT,
  title={A thallium transport FLIPR-based assay for the identification of KCC2-positive modulators.},
  author={Di Zhang and Sujatha M Gopalakrishnan and Gail M. Freiberg and Carol S. Surowy},
  journal={Journal of biomolecular screening},
  year={2010},
  volume={15 2},
  pages={177-84}
}
KCC2, potassium chloride cotransporter 2, is expressed exclusively in the CNS (on inhibitory neurons) and plays a major role in maintaining appropriately low intracellular chloride levels that ensure inhibitory actions of GABA(A) and glycine receptors. As such, it plays a pivotal role in inhibitory mechanisms that control neuronal excitation in the CNS. KCC2 downregulation has been implicated in various excitatory disorders, such as epilepsy and neuropathic pain. Positive modulators of KCC2… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 42 references

s, faaland ca, warner f, logue pJ, erickson sJ, et al: cloning, characterization, and gene organization of K-cl cotransporter from pig and human kidney and c. elegans

Holtzman eJ, Kumar
Am J Physiol • 1998
View 8 Excerpts
Highly Influenced

iii: molecular cloning and functional expression of the bumetanide-sensitive na-K-cl cotransporter

Xu Jc, lytle c, +3 authors B forbush
Proc Natl Acad Sci USA • 1994
View 8 Excerpts
Highly Influenced

chung td, oldenburg Kr: a simple statistical parameter for use in evaluation and validation of high throughput screening assays

JH Zhang
J Biomol Screen 1999;4:67-73 • 1999
View 3 Excerpts
Highly Influenced

Small-molecule screen identifies inhibitors of the neuronal K-Cl cotransporter KCC2.

Proceedings of the National Academy of Sciences of the United States of America • 2009

roles of the cation - chloride cotransporters in neurological disease

Kahle Kt, KJ staley, BV nahed, G Gamba, Hebert sc
Nat Clin Pract Neurol • 2008

Characterization of glial cell K-Cl cotransport.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology • 2007

Similar Papers

Loading similar papers…