A thalamic input to the nucleus accumbens mediates opiate dependence

  title={A thalamic input to the nucleus accumbens mediates opiate dependence},
  author={Yingjie Zhu and Carl F. R. Wienecke and Gregory Nachtrab and Xiaoke Chen},
Chronic opiate use induces opiate dependence, which is characterized by extremely unpleasant physical and emotional feelings after drug use is terminated. Both the rewarding effects of a drug and the desire to avoid withdrawal symptoms motivate continued drug use, and the nucleus accumbens is important for orchestrating both processes. While multiple inputs to the nucleus accumbens regulate reward, little is known about the nucleus accumbens circuitry underlying withdrawal. Here we identify the… CONTINUE READING


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