A tetrapyrrole-regulated ubiquitin ligase controls algal nuclear DNA replication

@article{Kobayashi2011ATU,
  title={A tetrapyrrole-regulated ubiquitin ligase controls algal nuclear DNA replication},
  author={Yuki Kobayashi and Sousuke Imamura and Mitsumasa Hanaoka and Kan Tanaka},
  journal={Nature Cell Biology},
  year={2011},
  volume={13},
  pages={483-487}
}
In plant cells, organelle DNA replication (ODR) is coordinated with nuclear DNA replication (NDR), with ODR preceding NDR during cell cycle progression. We previously showed that the occurrence of ODR is signalled by a tetrapyrrole compound, most likely Mg-protoporphyrin IX (Mg-ProtoIX), resulting in the activation of cyclin-dependent kinase A (CDKA) and consequent initiation of NDR (refs 1, 2, 3). Here we identify an F-box protein of SCF-type E3 ubiquitin ligase (Fbx3) in the red alga… CONTINUE READING