A tetrahedral DNA nanoflare for fluorometric determination of nucleic acids and imaging of microRNA using toehold strands

@article{Li2019ATD,
  title={A tetrahedral DNA nanoflare for fluorometric determination of nucleic acids and imaging of microRNA using toehold strands},
  author={Liang Li and Yingcai Meng and Lisheng Li and Shengfeng Wang and Jinsong Ding and Wenhu Zhou},
  journal={Microchimica Acta},
  year={2019},
  volume={186}
}
  • Liang Li, Yingcai Meng, +3 authors Wenhu Zhou
  • Published in Microchimica Acta 2019
  • Medicine, Chemistry
  • The authors describe a tetrahedral DNA nanostructure loaded with SYBR Green (SG-TDN) for fluorometric determination of nucleic acids. After intercalating into the TDN, fluorescence of SG is enhanced by 260-fold (exc 480 nm, em 524 nm), and the resulting SG-TDN nanoflare displays >7-fold stronger fluorescence than that of FAM-labeled TDN. The SG-TDNs were coupled to magnetic microparticles and polydopamine nanoparticles to construct multi-functional nanoprobes through sequence hybridization… CONTINUE READING

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