A tetracycline-regulated adenovirus encoding dominant-negative caspase-9 is regulated in rat brain and protects against neurotoxin-induced cell death in vitro, but not in vivo.

@article{Ebert2005ATA,
  title={A tetracycline-regulated adenovirus encoding dominant-negative caspase-9 is regulated in rat brain and protects against neurotoxin-induced cell death in vitro, but not in vivo.},
  author={Allison D. Ebert and Feng Chen and Xiaolong He and Vincent L Cryns and Martha C. Bohn},
  journal={Experimental neurology},
  year={2005},
  volume={191 Suppl 1},
  pages={S80-94}
}
Caspase-9 is a critical downstream effector molecule involved in apoptosis, a cell death process thought to be involved in the demise of dopamine (DA) neurons in the substantia nigra (SN) affected by Parkinson's disease (PD). In this study, we determined that a tetracycline-regulated adenovirus harboring a dominant-negative form of caspase-9 (Casp9DN) and… CONTINUE READING