A testis-expressed Zn finger gene (ZNF76) in human 6p21.3 centromeric to the MHC is closely linked to the human homolog of the t-complex gene tcp-11.

@article{Ragoussis1992ATZ,
  title={A testis-expressed Zn finger gene (ZNF76) in human 6p21.3 centromeric to the MHC is closely linked to the human homolog of the t-complex gene tcp-11.},
  author={Jiannis Ragoussis and Gabriele Senger and Ian Mockridge and Philippe Sanseau and Suzanne Ruddy and Keith Dudley and Denise Sheer and John Trowsdale},
  journal={Genomics},
  year={1992},
  volume={14 3},
  pages={
          673-9
        }
}
A novel testis-expressed Zn finger gene (ZNF76) was identified by screening cDNA libraries with cosmids derived from 6p21. ZNF76 is a member of the GLI-Krüppel family of DNA binding proteins. It is conserved in mouse where transcription in testis is initiated at Day 20 after birth. The mouse tcp-11 gene is located in the distal inversion of the t-complex and is developmentally regulated in the same manner as ZNF76. The human homolog of tcp-11 was isolated to allow a precise chromosomal… Expand
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  • 2000
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TLDR
Results of Northern blot and RT-PCR analyses of RNA extracted from human tissues revealed that the gene is only expressed in fertile adult testes, but not in azoospermictestes, fetal testes nor in other human tissues. Expand
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