A testicular germ cell-associated serine-threonine kinase, MAK, is dispensable for sperm formation.

@article{Shinkai2002ATG,
  title={A testicular germ cell-associated serine-threonine kinase, MAK, is dispensable for sperm formation.},
  author={Yoichi Shinkai and Hideo Satoh and Naoki Takeda and Mikiko Fukuda and Emiko Chiba and Tomoya Kato and Takashi Kuramochi and Yoshihiko Araki},
  journal={Molecular and cellular biology},
  year={2002},
  volume={22 10},
  pages={
          3276-80
        }
}
A member of the mitogen-activated protein kinase superfamily, MAK, has been proposed to have an important role in spermatogenesis, since Mak gene expression is highly restricted to testicular germ cells. To assess the biological function of MAK, we have established MAK-deficient (Mak(-/-)) mice. Mak(-/-) mice developed normally, and no gross abnormalities were observed. Spermatogenesis of the Mak(-/-) mice was also intact, and most of the mice were fertile. However, Mak(-/-) male-derived litter… CONTINUE READING

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