A tension-based theory of morphogenesis and compact wiring in the central nervous system

@article{Essen1997ATT,
  title={A tension-based theory of morphogenesis and compact wiring in the central nervous system},
  author={D. V. Essen},
  journal={Nature},
  year={1997},
  volume={385},
  pages={313-318}
}
Many structural features of the mammalian central nervous system can be explained by a morphogenetic mechanism that involves mechanical tension along axons, dendrites and glial processes. In the cerebral cortex, for example, tension along axons in the white matter can explain how and why the cortex folds in a characteristic species-specific pattern. In the cerebellum, tension along parallel fibres can explain why the cortex is highly elongated but folded like an accordion. By keeping the… Expand
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